201 Tooth extractions and weight loss in OPSCC 6 Table 2 – Continued Stable weight or less than 5% loss during CRT/BRT n = 37 (48%) >5% weight loss during CRT/BRT n = 40 (52%) p value RT dose to contralateral submandibular gland (Gy); mean ± SD 48.1 ± 12.0* 49.7 ± 10.6* 0.529b RT dose to contralateral parotid salivary gland (Gy); mean ± SD 24.2 ± 10.5 22.2 ± 7.1 0.345b RT dose to superior PCM (Gy); mean ± SD 59.3 ± 11.6 59.3 ± 7.5 0.995b RT dose to middle PCM (Gy); mean ± SD 59.8 ± 6.4 60.1 ± 7.1 0.870b RT dose to inferior PCM (Gy); mean ± SD 49.4 ± 10.8 49.5 ± 8.4 0.939b RT dose to oral cavity (Gy); mean ± SD 45.9 ± 11.0 45.2 ± 9.5 0.740b RT dose to cricopharyngeal muscle (Gy); mean ± SD 44.5 ± 7.3 43.3 ± 6.5 0.433b RT dose to cervical esophagus (Gy) mean ± SD 41.5 ± 8.3 37.0 ± 11.1 median (IQR) 42.0 (8.0) 40.1 (17.7) 0.129c TF during CRT/BRT (any duration) 24 (65%) 23 (58%) 0.508d No TF 13 (35%) 17 (43%) Abbreviations: BMI, body mass index; CCI, Charlson comorbidity index; CRT/BRT, chemoradiotherapy or bioradiotherapy; WHO PS, World Health Organization performance status; p16+/-, p16 positive/negative tumor as surrogate marker for Human Papilloma Virus; PCM, pharyngeal constrictor muscles; RT, radiotherapy; TF, tube feeding; TNM-classification, tumor (T), node (N), metastasis (M) classification according to the 7th edition [44]. Bold values denote statistical significance at the p<.05 level. aFisher’s exact test. bIndependent T-test. cMann-Whitney U test. dChi2-test. *two missing values due to a bilateral neck dissection Univariable logistic regression analysis for significant weight loss during CRT/ BRT revealed a potential associative value (p value <.10) for the factors BMI, tooth extractions, tooth extractions and/or additional interventions, and RT dose to the cervical esophagus (Table 3).
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