204 Chapter 6 In multivariable step backward logistic regression analyses, tooth extractions prior to CRT/BRT and BMI at start of CRT/BRT remained as associative factors for weight loss >5% during CRT/BRT, independent of weight loss prior to CRT/BRT, WHO PS, CCI, dental status at first assessment or at start CRT/BRT, number of occlusal units (OU), and number of removed teeth (Table 3). When evaluating the individual influence of potential associative factors, the associative value of extractions was reduced to a trend when corrected for alcohol use (p = .057). Univariable logistic regression analysis for TF dependency during CRT/BRT revealed a potential associative value (p value <.10) for the following factors: Weight loss prior to CRT/BRT, type of systemic therapy (cisplatin or cetuximab), RT dose to the contralateral submandibular gland, RT dose to the cricopharyngeal muscle, and RT dose to the cervical esophagus. None of the dental state parameters showed any significant associative value for TF dependency. In multivariable analysis, only a higher RT dose to the contralateral submandibular gland and type of systemic therapy (cisplatin) remained significant associative factors for the risk of TF dependency (Table 3).
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