Contents Chapter 1 General introduction 9 Aims and outline of this thesis 23 Chapter 2 Prosthetic rehabilitation of head and neck cancer patients focusing on mandibular dentures in irradiated patients. 27 Chapter 3 Translation, cross-cultural adaptation, and validation of the Liverpool Oral Rehabilitation Questionnaire (LORQ) into the Dutch language. 43 Chapter 4.1 Masticatory performance and oral health-related quality of life in edentulous maxillectomy patients: A crosssectional study to compare implant-supported obturators and conventional obturators. 57 Chapter 4.2 Mastication in maxillectomy patients: A comparison between reconstructed maxillae and implant supported obturators: A cross-sectional study. 85 Chapter 5 The extent of unnecessary tooth loss due to extractions prior to radiotherapy based on radiation field and dose in patients with head and neck cancer. 105 Chapter 6 Tooth extractions prior to chemoradiation or bioradiation are associated with weight loss during treatment for locally advanced oropharyngeal cancer. 191 Chapter 7 General discussion 213 Chapter 8 Summary in English and Dutch 235 Chapter 9 Impact Paragraph 249 Appendix List of publications 255 Acknowledgement / Dankwoord 261 Curriculum Vitae 269
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