245 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment Supplementary Table 1: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for weakly stained PicroSirius Red area on day 7 samples Control Hydrogels IPF Hydrogels Empty Control Fb IPF Fb Empty Control Fb IPF Fb Control Hydrogels Empty 0.478 0.364 0.583 Control Fb 0.478 0.111 IPF Fb 0.364 0.111 IPF Hydrogels Empty 0.583 0.273 0.489 Control Fb 0.273 0.079 IPF Fb 0.489 0.079 Not significant Significant Comparison not applicable Supplementary Figure 3: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for the estimates of weakly stained PicroSirius Red (PSR) area (%) for day 7 samples. 9
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