247 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment Supplementary Table 3: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for moderately stained PicroSirius Red area on day 7 samples Control Hydrogels IPF Hydrogels Empty Control Fb IPF Fb Empty Control Fb IPF Fb Control Hydrogels Empty 0.465 0.398 0.462 Control Fb 0.639 0.121 IPF Fb 0.412 0.201 IPF Hydrogels Empty 0.955 0.350 0.263 Control Fb 0.230 0.045 IPF Fb 0.584 0.045 Not significant Significant Comparison not applicable Supplementary Figure 5: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for the estimates of moderately stained PicroSirius Red (PSR) area (%) for day 7 samples. 9
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