249 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment Supplementary Table 5: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for strongly stained PicroSirius Red area on day 7 samples Control Hydrogels IPF Hydrogels Empty Control Fb IPF Fb Empty Control Fb IPF Fb Control Hydrogels Empty 0.639 0.412 0.955 Control Fb 0.639 0.201 IPF Fb 0.412 0.201 IPF Hydrogels Empty 0.955 0.230 0.584 Control Fb 0.230 0.507 IPF Fb 0.584 0.507 Not significant Significant Comparison not applicable Supplementary Figure 7: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for the estimates of strongly stained PicroSirius Red (PSR) area (%) for day 7 samples. 9
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