255 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment Supplementary Table 11: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for mean intensity of strongly stained PicroSirius Red on day 7 samples Control Hydrogels IPF Hydrogels Empty Control Fb IPF Fb Empty Control Fb IPF Fb Control Hydrogels Empty 0.702 0.431 0.903 Control Fb 0.702 0.246 IPF Fb 0.431 0.246 IPF Hydrogels Empty 0.903 0.538 0.612 Control Fb 0.538 0.914 IPF Fb 0.612 0.914 Not significant Significant Comparison not applicable Supplementary Figure 13: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for the estimates of mean intensity of strongly stained PicroSirius Red (PSR) area (au) for day 7 samples. 9
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