277 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment Supplementary Table 33: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for stiffness on day 7 samples Control Hydrogels IPF Hydrogels Empty Control Fb IPF Fb Empty Control Fb IPF Fb Control Hydrogels Empty 0.497 0.846 4.93 x 10-²² Control Fb 0.497 0.639 IPF Fb 0.846 0.639 IPF Hydrogels Empty 4.93 x 10-²² 0.002 0.006 Control Fb 0.002 0.658 IPF Fb 0.006 0.658 Not significant Significant Comparison not applicable Supplementary Figure 35: Individual comparisons between the different groups of empty and fibroblast-seeded control and IPF hydrogels for the estimates of stiffness of hydrogels (kPa) for day 7 samples. 9
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