Mehmet Nizamoglu

285 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the threedimensional microenvironment 14. Parker MW, Rossi D, Peterson M, Smith K, Sikstrom K, White ES, Connett JE, Henke CA, Larsson O, Bitterman PB. Fibrotic extracellular matrix activates a profibrotic positive feedback loop. J Clin Invest 2014: 124(4): 1622-1635. 15. Matera DL, DiLillo KM, Smith MR, Davidson CD, Parikh R, Said M, Wilke CA, Lombaert IM, Arnold KB, Moore BB, Baker BM. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation. Sci Adv 2020: 6(37). 16. Campbell DR, Jr., Senger CN, Ryan AL, Magin CM. Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine. Front Med 2021: 8: 647834. 17. Bailey KE, Floren ML, D’Ovidio TJ, Lammers SR, Stenmark KR, Magin CM. Tissue-informed engineering strategies for modeling human pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 2019: 316(2): L303-L320. 18. Saldin LT, Cramer MC, Velankar SS, White LJ, Badylak SF. Extracellular matrix hydrogels from decellularized tissues: Structure and function. Acta Biomater 2017: 49: 1-15. 19. Wagner DE, Bonvillain RW, Jensen T, Girard ED, Bunnell BA, Finck CM, Hoffman AM, Weiss DJ. Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds. Respirology 2013: 18(6): 895-911. 20. Radwanska A, Cottage CT, Piras A, OveredSayer C, Sihlbom C, Budida R, Wrench C, Connor J, Monkley S, Hazon P, Schluter H, Thomas MJ, Hogaboam CM, Murray LA. Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis. JCI Insight 2022: 7(16). 21. Vasse GF, Van Os L, De Jager M, Jonker MR, Borghuis T, Van Den Toorn LT, Jellema P, White ES, Van Rijn P, Harmsen MC, Heijink IH, Melgert BN, Burgess JK. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices. Front Pharmacol 2021: 12: 669037. 22. Blokland KEC, Habibie H, Borghuis T, Teitsma GJ, Schuliga M, Melgert BN, Knight DA, Brandsma C-A, Pouwels SD, Burgess JK. Regulation of Cellular Senescence Is Independent from Profibrotic FibroblastDeposited ECM. Cells 2021: 10(7): 1628. 23. Tilbury K, Hocker J, Wen BL, Sandbo N, Singh V, Campagnola PJ. Second harmonic generation microscopy analysis of extracellular matrix changes in human idiopathic pulmonary fibrosis. J Biomed Opt 2014: 19(8): 086014. 24. Tisler M, Alkmin S, Chang HY, Leet J, Bernau K, Sandbo N, Campagnola PJ. Analysis of fibroblast migration dynamics in idiopathic pulmonary fibrosis using image-based scaffolds of the lung extracellular matrix. Am J Physiol Lung Cell Mol Physiol 2020: 318(2): L276-L286. 25. Philp CJ, Siebeke I, Clements D, Miller S, Habgood A, John AE, Navaratnam V, Hubbard RB, Jenkins G, Johnson SR. Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis. Am J Respir Cell Mol Biol 2018: 58(5): 594-603. 26. Grønlien KG, Pedersen ME, Rønning SB, Solberg NT, Tønnesen HH. Tuning of 2D cultured human fibroblast behavior using lumichrome photocrosslinked collagen hydrogels. Mater Today Commun 2022: 31: 103635. 9

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