308 Appendices fibroblast to the existing differences between the IPF and non-IPF lung ECM-derived hydrogels, it was possible to show that both cell and microenvironment origin play a crucial role in determining the ECM remodeling responses of fibroblasts. Overall, this thesis furthers our understanding on the complex cell:matrix interactions and demonstrates the overruling capacity of fibrotic ECM in the context of lung fibrosis either by providing new mechanisms by which fibrotic ECM acts or by providing innovative and advanced methodologies to recreate lung microenvironment in vitro.
RkJQdWJsaXNoZXIy MTk4NDMw