321 Acknowledgements Parts of the scientific output I have generated ended up as the chapters in this thesis; however, some of them did not. Still, this did not take anything away from my gratitude to each and every co-author with whom I have had chance to work with on different manuscripts. I would like to thank Sai Sneha Priya Nemani, Markus Weckmann, YiWen Fan, Janesh Pillay, Catarina Almeda, Jorge Otero, Linda Elowsson, Anne-Karin Callerfelt, Isabelle Dupin, Pauline Henrot, Lisette van Os, Olivier Guenat, Ramon Farre, Joris van Dongen, Harold de Bruin, Karla Arevalo Gomez, Nick ten Hacken, Geke Teitsma, Michael Schuliga, Daryl Knight, Vasilena Getova, Meng Zhang for the manuscripts we worked on together. I also would like to express my appreciation to the committees/councils I’ve had the privilege to get involved with: giving back to the scientific community (mostly PhDs) together with you was fulfilling and fun at the same time! To my dear GUIDE PhD Council members: Matthijs, Rita, Yehya, Juan, Noura, Yang, Sara, Erika and Mugdha, thank you for making and keeping every first Thursday of the month interesting with our discussions and brainstorming. I wish you all the best in finalizing your PhDs! To the Dutch Society for Matrix Biology (NVMB) Early Stage Researcher Committee members: Niek, Matthew, Josette, Mugdha and Abdullah, thank you for adding an additional source of fun to the annual meetings we had in the last couple of years. To the Industry Perspectives in Medicine (IPIM) Summer School Organizing committee members from 2020 and 2021 editions: Gerben, Eline S., Eline J., Ariel and Freek, I have had a blast in organizing and running the two summer schools with you guys. I also would like to thank to the Dutch Society for Matrix Biology (NVMB), Netherlands Respiratory Society (NRS) and Stitching Bestrijden Asthma (SAB) for the financial support during my PhD trajectory. I am also grateful to Junko Hashiguchi for the help with the original quote and translation in the dedication text. There are two people, who are in the same journey as I have been since the very beginning, from our undergraduate study years. Regardless of the distance and time differences, we have been many things to each other: a safe haven for venting, a shoulder to cry, a critical eye when needed and unconditional support. Bilge and Muge, I am extremely grateful to your helps over the last not four but ten years. I know for sure that many things became easier and possible thanks to your support, and I appreciate our efforts to stay in touch both personally and academically between the different combinations of Turkey-Germany-Sweden-NetherlandsUSA. Thank you for all you’ve done, and for all you’ve contributed.
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