76 Chapter 4 Figure 1: A general comparison of in vitro models used for modelling the lung: precision cut lung slices (PCLS), organoids, lung extracellular matrix (ECM)-derived hydrogels and lung-on-chip (LOC). E/M/V/I: Epithelial cells, Mesenchymal cells, Vascular cells, Immune cells. The proportion of filled dots reflects the score, on a scale of 5, of the model to fulfil the stated criterion from least representative (1 filled dot) to a complete lung in vitro (5 filled dots). Lung ECM-derived hydrogel comparisons were based on cell-seeded hydrogels. Reported scores reflect the opinion of the authors and the meeting attendees rather than an objective scoring.
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