Mehmet Nizamoglu

Chapter 1 General Introduction	9
Chapter 2 The multi-faceted extracellular matrix: unlocking its secrets for understanding the perpetuation of lung fibrosis	17
Chapter 3 Abnormal collagen structure resulting from lack of contribution of collagen type XIV in lungs of patients with idiopathic pulmonary fibrosis	57
Chapter 4 Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research	71
Chapter 5 Dysregulated cross talk between alveolar epithelial cells and stromal cells in IPF reduces epithelial regenerative capacity	111
Chapter 6 3D lung models – 3D extracellular matrix models	127
Chapter 7 Current possibilities and future opportunities with three dimensional lung ECM-derived hydrogels	165
Chapter 8: An in invitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition	183
Chapter 9 Fibroblast remodeling of extracellular matrix is directed by the fibrotic nature of the three-dimensional microenvironment	217
Chapter 10 General discussion and future perspectives	289
English summary	306
Nederlandse samenvatting	309
Acknowledgements	312
Curriculum vitae	323
List of publications	324

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