7 CHAPTER 7 146 Figure 1 Manhattan plot showing genome-wide significant loci associated with cluster headache (4,043 cases, 21,729 controls). The horizontal axis shows the chromosomal position and the vertical axis shows the significance (-log10 p value) of tested markers. Each dot represents a genetic variant. The threshold for genome-wide significance (p < 5 × 10–8) is indicated by a red dotted line, and genome-wide significance loci are shown in blue. Figure 2 Quantile-quantile (Q-Q) plot for association with cluster headache. The horizontal axis shows -log10 p values expected under the null distribution. The vertical axis shows observed -log10 p values. Genomic inflation factor (λ) = 1.086. Red = common variants (MAF ≥ 5%), blue = low frequency variants (MAF = 0.5 - 5%), green = rare variants (MAF = 0.1 - 0.5%), purple = very rare variants (MAF < 0.1%). MAF = minor allele frequency; SNPs = single nucleotide polymorphisms.
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