CLUSTER HEADACHE GENOME-WIDE ASSOCIATION STUDY AND META-ANALYSIS IDENTIFIES EIGHT LOCI AND IMPLICATES SMOKING AS CAUSAL RISK FACTOR 149 7 Figure 5 Tissue enrichment for the putative causal genes. Enrichment of the 20 genes with supportive evidence for implication in cluster headache in differentially expressed gene (DEG) sets for 54 tissues from GTEXv8.The analysis was performed using FUMA and based on pre-calculated DEG sets defined by a two-sided t-test per tissue versus all other tissues.The red line shows the significance threshold after adjustment for multiple testing by Bonferroni correction (p = 0.05/54 tests = 9.26 x 10-4).
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