8 CHAPTER 8 172 Figure 1 Manhattan plot of migraine GWAS meta-analysis (n = 873,341; 102,084 cases and 771,257 controls) On the x-axis, variants are plotted along the 22 autosomes and the X chromosome. y-axis shows the statistical strength of the association from the inverse-variance weighted fixed-effect meta-analysis as the negative log10 of the uncorrected two-sided P-value. Horizontal line is the genome-wide significance threshold (P = 5 × 10 -8 ). The 123 risk loci passing the threshold are divided into 86 new loci (purple) and 37 previously known loci (green). Adjacent chromosomes are colored in different shades of blue. Plotted are variants with P < 0.001.
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