GENOME-WIDE ANALYSIS OF 102,084 MIGRAINE CASES IDENTIFIES 123 RISK LOCI AND SUBTYPE-SPECIFIC RISK ALLELES 177 8 Figure 2 LocusZoom plots of two novel migraine loci with genes that are targets of recent migraine specific drugs A) Locus containing CALCA and CALCB genes, encoding CGRP, which is the target of preventive and acute therapies via monoclonal antibodies and gepants. B) Locus containing the HTR1F gene, which encodes a serotonin 5-HT1F receptor that is the target of acute therapies via ditans. x-axis shows the chromosomal location, and y-axis shows the uncorrected two-sided negative log10 P-value from the inverse-variance weighted fixed-effects meta-analysis with 102,084 cases and 771,257 controls. The squared correlation to the lead variant is shown by colors based on the UK Biobank data for variants that have an effective sample size ± 20% of the lead variant’s effective sample size. Horizontal line corresponds to P = 5 × 10-8. Blue graph shows the recombination rate.
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