8 CHAPTER 8 178 Figure 3 Lead variants stratified by migraine subtype for risk loci with minor allele frequency > 5% A) Axes show the negative log10 P-value of MO (x-axis; n = 697,356, 15,055 MO cases and 682,301 controls) and MA (y-axis; n = 718,476, 14,624 MA cases and 703,852 controls) analyses. Two-sided P-values are derived from inverse-variance weighted fixed-effect meta-analyses and are uncorrected. Symbols that are colored and annotated indicate > 95% posterior probability that a non-zero effect is present in both MO and MA (model BOTH), or that the effect is present only in MO or only in MA but not both (models MO and MA, respectively). Variants with a probability less than 95% for each of the three models are shown as gray. Dashed lines show the genome-wide significance threshold (P = 5 × 10 -8 ). B) Axes show logarithm of odds ratios for MO (x-axis; n = 697,356, 15,055 MO cases and 682,301 controls) and MA (y-axis; n = 718,476, 14,624 MA cases and 703,852 controls) calculated for the migraine risk allele. The effects at variants that have been colored and annotated differ between the subtypes at significance level of 0.0004 = 0.05/123. The 95% confidence intervals for the logarithm of odds ratios are shown for the annotated variants. Dashed lines show the coordinate axes and the diagonal. MO, migraine without aura; MA, migraine with aura.
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