GENOME-WIDE ANALYSIS OF 102,084 MIGRAINE CASES IDENTIFIES 123 RISK LOCI AND SUBTYPE-SPECIFIC RISK ALLELES 187 8 68. Hinrichs AS, Karolchik D, Baertsch R, et al. The UCSC Genome Browser Database: update 2006. Nucleic Acids Res. 2006;34:D5908. 69. Nagel M, Jansen PR, Stringer S, et al. Metaanalysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat Genet. 2018;50(7):920-927. 70. Pardiñas AF, Holmans P, Pocklington AJ, et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018;50(3):381-389. 71. Howard DM, Adams MJ, Clarke T-K, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019;22(3):343-352. 72. Yang J, Weedon MN, Purcell S, et al. Genomic inflation factors under polygenic inheritance. Eur J Hum Genet. 2011;19(7):807-812. 73. Do TP, Guo S, Ashina M. Therapeutic novelties in migraine: new drugs, new hope? J Headache Pain. 2019;20(1):37. 74. Kurth T, Winter AC, Eliassen AH, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ. 2016;353:i2610. 75. Hippisley-Cox J, Coupland C, Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ. 2017;357:j2099. 76. Adelborg K, Szépligeti SK, Holland-Bill L, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ. 2018;360:k96. 77. Siewert KM, Klarin D, Damrauer SM, et al. Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. Int J Epidemiol. 2020;49(3):1022-1031. 78. Guo Y, Rist PM, Daghlas I, et al. A genomewide cross-phenotype meta-analysis of the association of blood pressure with migraine. Nat Commun. 2020;11(1):3368. 79. Need AC,Goldstein DB.Schizophrenia Genetics Comes of Age. Neuron. 2014;83(4):760-763. 80. Gormley P, Kurki M, Kurki MI, et al. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 2018;98(4):743-753.e4. 81. Chasman DI, Anttila V, Buring JE, et al. Selectivity in genetic association with sub-classified migraine in women. PLoS Genet. 2014;10(5):e1004366. 82. Nyholt DR, Anttila V, Winsvold BS, et al. Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies. Cephalalgia. 2015;35(6):48999. 83. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996;87(3):543-552. 84. de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AMJM. Molecular genetics of migraine. Hum Genet. 2009;126(1):115-132. 85. Zhao H, Eising E, de Vries B, et al. Genebased pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia. 2016;36(7):648-57. 86. Jacobs B, Dussor G. Neurovascular contributions to migraine: Moving beyond vasodilation. Neuroscience. 2016;338:130-144. 87. Hoffmann J, Baca SM, Akerman S. Neurovascular mechanisms of migraine and cluster headache. J Cereb Blood Flow Metab. 2019;39(4):573-594. 88. Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB. Migraine and cardiovascular disease: possible mechanisms of interaction. Neurology. 2009;72(21):1864-1871. 89. Malik R, Freilinger T, Winsvold BS, et al. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology. 2015;84(21):2132-2145. 90. Winsvold BS, Nelson CP, Malik R, et al. Genetic analysis for a shared biological basis between migraine and coronary artery disease. NeurologyGenetics. 2015;1(1):e10.
RkJQdWJsaXNoZXIy MTk4NDMw