8 CHAPTER 8 188 91. Mahmoud AN, Mentias A, Elgendy AY, et al. Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects. BMJ open. 2018;8(3):e020498. 92. Daghlas I, Guo Y, Chasman DI. Effect of genetic liability to migraine on coronary artery disease and atrial fibrillation: a Mendelian randomization study. Eur J Neurol. 2020;27(3):550-556. 93. Charles A. The pathophysiology of migraine: implications for clinical management. The Lancet Neurology. 2018;17(2):174-182. 94. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015;35(17):66196629. 95. Andreou AP, Edvinsson L. Mechanisms of migraine as a chronic evolutive condition. J Headache Pain. 2019;20(1):117. 96. Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral sensitisation. The Lancet Neurology. 2009;8(7):679-690. 97. Brandes JL. The influence of estrogen on migraine: a systematic review. JAMA. 2006;295(15):1824-1830. 98. Borsook D, Erpelding N, Lebel A, et al. Sex and the migraine brain. Neurobiol Dis. 2014;68:200-14. 99. Delaruelle Z, Ivanova TA, Khan S, et al. Male and female sex hormones in primary headaches. J Headache Pain. 2018;19(1):117. 100. Diener H-C. CGRP antibodies for migraine prevention — new kids on the block. Nature Reviews Neurology. 2019;15(3):129-130. 101. deVriesT,Villalón CM,MaassenVanDenBrink A. Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans. Pharmacol Ther. 2020:107528. 102. Nelson MR, Tipney H, Painter JL, et al. The support of human genetic evidence for approved drug indications. Nat Genet. 2015;47(8):856-860. 103. King EA, Davis JW, Degner JF. Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval. PLoS Genet. 2019;15(12):e1008489. 104. Wainberg M, Sinnott-Armstrong N, Mancuso N, et al. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019;51(4):592-599.
RkJQdWJsaXNoZXIy MTk4NDMw