METABOLIC PROFILE CHANGES IN SERUM OF MIGRAINE PATIENTS DETECTED USING 1H-NMR SPECTROSCOPY 41 2 Supplementary information Additional file 1. DOC. file with an overview of signals identified in the 2-dimensional J-resolved 1H-NMR spectrum and performed transformations https://static-content.springer.com/esm/art%3A10.1186%2Fs10194-021-01357-w/ MediaObjects/10194_2021_1357_MOESM1_ESM.docx Additional file 2. PDF. file with ratio stratification plots for sex, age BMI and smoking status in lifetime migraine patients and active migraine patients https://static-content.springer.com/esm/art%3A10.1186%2Fs10194-021-01357-w/ MediaObjects/10194_2021_1357_MOESM2_ESM.png Abbreviations: 1H-NMR: Proton nuclear magnetic resonance spectroscopy; ERF: Erasmus Rucphen Family; JRES: J-resolved spectra; CPMG: Purcell-Meiboom-Gill; OR: Odds ratio; CI: Confidence interval; CGRP: Calcitonin gene-related peptide Ethics approval and consent to participate: The study was approved by the medical ethics committee of Erasmus University Medical Centre. All subjects provided written informed consent prior to the study. Availability of data and materials: The data used and/or analysed during the current study are available from the corresponding author on reasonable request. Competing interests: The authors declare that they have no competing interests Funding: This work was supported by grants from the Netherlands Organization for Scientific Research (NWO) (907-00-217,G.M.T;VIDI 91711319,G.M.T.);the Centre for Medical Systems Biology (CMSB) and Netherlands Consortium for Systems Biology (NCSB), both within the framework of the Netherlands Genomics Initiative (NGI)/NWO (to A.M.J.M.v.d.M.); and the FP7 EU project EUROHEADPAIN (no. 602633) (to A.M.J.M.v.d.M. and G.M.T.). They had
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