2 CHAPTER 2 42 no role in the design or conduct of the study. The ERF study is part of EUROSPAN (European Special Populations Research Network) FP6 STRP (no.018947 LSHG-CT-2006-01947) and also received funding from the European Community’s Seventh Framework Programme (FP7/20072013)/grant agreement HEALTH-F4-2007-201413 by the European Commission under the programme “Quality of Life and Management of the Living Resources” of 5th Framework Programme (no. QLG2-CT-2002-01254) as well as FP7 project EUROHEADPAIN (nr 602633). Author’s contributions: AMJMvdM, GMT designed the study design. PH and AVEH were involved in the 1H-NMR measurements and/or annotation. PH, AVEH and LSV performed the statistical analyses. All authors contributed to the interpretation of results. AVEH made the figures and wrote the initial draft of the manuscript. All authors critically revised and approved the final version for submission. Acknowledgements: Thanks to all study participants from the Erasmus Rucphen Family and their relatives, general practitioners, and neurologists for their contributions. We thank Dr. Oleg A. Mayboroda, from the Center for Proteomics and Metabolomics (LUMC), in which the NMR analyses were done, for critical reading of the manuscript and Dr. Boukje de Vries for technical help and support.
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