Table of Contents Chapter 1 General introduction 7 Part I Biochemistry of migraine Chapter 2 Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy 29 Chapter 3 Correlation between plasma and CSF concentrations of amines 49 Chapter 4 Endocannabinoid cerebrospinal fluid levels in migraine 75 Chapter 5 Prostaglandin-E2 levels over the course of glyceryl trinitrate provoked migraine attacks 95 Part II Genetics of different headache forms Chapter 6 Genetic susceptibility loci in genome-wide association study of cluster headache 115 Chapter 7 Cluster headache genome-wide association study identifies eight loci and implicates smoking as causal risk factor 137 Chapter 8 Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 159 Chapter 9 Whole exome sequencing of hemiplegic migraine patients shows an increased burden of missense variants in CACNA1H and CACNA1I genes 191 Chapter 10 General discussion 209 Appendices Summary 236 Nederlandse samenvatting 241 List of publications 247 About the author 249 Dankwoord 250
RkJQdWJsaXNoZXIy MTk4NDMw