CORRELATING RATIOS OF AMINES IN PLASMA AND CEREBROSPINAL FLUID 57 3 Table 2 Plasma and CSF concentrations in healthy controls Metabolite Plasma (µM) CSF† (µM) Plasma/ CSF Ratio Median Q1 Q3 Median Q1 Q3 Median Ethanolamine 12.088 11.004 13.338 22.679 20.239 24.404 .55 Putrescine .105 .083 .13 .161 .123 .198 .67 L-Glutamine 665.43 600.158 714.841 591.26 538.944 637.634 1.12 N6-N6-N6-Trimethyl-L-lysine .468 .39 .568 .404 .365 .447 1.17 Gamma-aminobutyric acid .146 .123 .169 .099 .071 .121 1.51 L-Homoserine .134 .12 .15 .06 .053 .066 2.25 Gamma-Glutamylglutamine 4.693 4.109 5.715 1.98 1.778 2.226 2.36 L-Arginine 78.796 66.678 94.937 24.216 21.507 26.295 3.4 L-Threonine 135.285 117.762 152.372 36.591 31.929 42.588 3.63 SDMA .61 .549 .68 .163 .139 .199 3.65 L-Serine 108.619 92.113 121.252 28.161 25.711 30.606 3.78 L-Histidine 60.536 55.485 65.125 15.007 13.649 16.842 4.11 Homocitrulline .258 .186 .331 .051 .037 .073 4.81 L-Phenylalanine 55.817 51.336 62.03 10.273 9.267 11.781 5.41 L-Alpha-aminobutyric acid 18.218 14.484 21.797 3.242 2.518 3.757 5.72 L-Methionine 23.506 21.018 26.282 3.904 3.544 4.455 5.8 L-Tyrosine 50.099 42.364 55.329 7.791 6.986 9.175 5.97 3-Methoxytyrosine .089 .077 .106 .015 .012 .017 6.11 Methionine sulfone .285 .242 .376 .047 .037 .063 6.17 L-Lysine 186.795 167.22 204.311 29.905 26.963 32.829 6.22 L-Asparagine 52.278 47.707 58.596 8.114 7.484 9.141 6.47 L-Methionine sulfoxide .736 .648 .828 .099 .082 .114 7.49 S-Methylcysteine 3.64 3.106 4.86 .461 .369 .622 7.92 L-2-aminoadipic acid .699 .583 .906 .082 .072 .1 8.22 L-Leucine 277.057 244.39 318.336 33.685 29.966 39.018 8.45 L-Alanine 359.072 317.329 421.116 34.465 29.743 43.473 10.06 L-Isoleucine 116.684 103.751 132.595 11.702 10.009 13.24 10.46 Ornithine 65.305 55.212 74.791 5.359 4.799 6.309 11.6 L-Valine 242.729 212.533 277.108 20.728 17.63 23.222 11.88 L-4-hydroxy-L-proline 7.569 5.951 10.286 .664 .474 .838 11.97 Gamma-L-glutamyl-L-alanine .507 .411 .61 .041 .036 .046 12.01 Citrulline 29.169 25.484 33.029 2.168 1.836 2.638 12.93 Taurine 97.824 71.535 127.601 7.397 6.461 8.244 13.03 Glutathione 5.577 4.595 6.355 .337 .275 .428 15.83 L-Tryptophan 56.353 49.209 63.568 2.385 2.146 2.703 23.28 Glycine 296.343 237.466 333.362 8.686 7.506 10.336 33.39 L-Pipecolic acid 11.26 9.687 13.694 .34 .258 .41 34.28 L-Glutamic acid 44.036 34.697 63.195 .399 .35 .447 110.32 L-Proline 178.184 140.29 218.478 .922 .751 1.233 183.31 Metabolites are ranked by plasma/CSF ratio from smallest to largest ratio. The table is based on pre-processed data. †CSF = cerebrospinal fluid; Q1 = First quartile; Q3 = Third quartile.
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