3 CHAPTER 3 58 Figure 1 Correlation plots of amines with strongest correlation between plasma and CSF in healthy controls Log10-transformed concentrations are plotted with plasma concentrations on the X-axis and CSF concentrations on the Y-axis. Values below [mean - 4 * SD] and above [mean + 4 * SD] were replaced with these cut-offs. Plots are based on uncorrected data. The black line indicates the linear regression line and the grey area the 95% confidence interval. CSF = cerebrospinal fluid. Amines in blood plasma and CSF of participants with migraine Concentrations of amines Amine concentrations in plasma and CSF were reliably measured for 197 migraine participants (n = 98 for migraine without aura MO, n = 99 for migraine with aura MA) (for clinical characteristics see Table 4). Plasma concentrations were higher than CSF concentrations for most amines in MO participants (Table 5) and MA participants (Table 6), similar to observations in healthy controls. Also in migraine samples ethanolamine and putrescine had higher concentrations in CSF than
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