3 CHAPTER 3 68 Table 5 Plasma and CSF concentrations in migraine without aura participants Metabolite Plasma (µM) CSF† (µM) Plasma/ CSF Ratio Median Q1 Q3 Median Q1 Q3 Median Ethanolamine 12.297 11.175 13.553 21.821 18.822 23.871 .58 Putrescine .100 .077 .125 .144 .115 .206 .62 L.Glutamine 674.580 595.338 752.180 589.130 515.600 637.313 1.19 O.Phosphoethanolamine 10.010 6.639 13.745 7.752 6.437 8.995 1.22 N6.N6.N6.Trimethyl.L.lysine .513 .418 .610 .384 .343 .454 1.28 Gamma.aminobutyric.acid .141 .127 .163 .100 .074 .129 1.41 L.Homoserine .132 .119 .144 .058 .053 .064 2.31 Gamma.Glutamylglutamine 5.014 4.231 5.832 2.091 1.833 2.386 2.49 L.Arginine 80.671 60.536 94.243 23.307 20.515 26.424 3.50 L.Threonine 134.514 116.573 156.030 37.440 32.806 44.239 3.62 SDMA .600 .540 .680 .152 .131 .190 3.79 L.Serine 104.086 95.945 119.437 27.274 24.831 31.276 3.95 L.Histidine 60.834 57.208 66.340 14.658 13.246 16.115 4.33 Homocitrulline .242 .170 .332 .049 .037 .074 4.83 L.Phenylalanine 56.070 52.176 60.344 10.093 8.901 11.138 5.77 L.Alpha.aminobutyric.acid 18.149 15.071 22.688 3.119 2.453 3.855 6.00 L.Tyrosine 49.079 43.117 55.010 8.053 6.849 9.219 6.20 L.Methionine 23.253 21.219 25.536 3.905 3.331 4.257 6.22 3.Methoxytyrosine .093 .083 .108 .015 .013 .017 6.31 Methionine.sulfone .304 .220 .381 .045 .035 .060 6.37 L.Asparagine 51.826 46.566 57.312 7.849 6.839 9.082 6.66 L.Lysine 200.450 175.718 217.740 29.707 24.925 34.051 6.68 L.Methionine.sulfoxide .723 .619 .806 .097 .081 .117 7.22 S.Methylcysteine 3.744 3.037 4.854 .464 .371 .647 8.14 L.Leucine 280.280 255.741 320.453 32.286 28.673 39.077 8.59 L.2.aminoadipic.acid .775 .648 .997 .092 .080 .104 8.61 L.Alanine 374.163 326.391 429.543 35.577 30.439 41.706 10.84 L.Isoleucine 118.753 104.690 133.144 11.132 9.200 13.814 11.03 Taurine 92.333 69.557 116.352 7.763 6.767 8.755 12.16 L.Valine 245.782 223.515 277.096 20.551 17.680 24.981 12.36 Gamma.L.glutamyl.L.alanine .532 .441 .672 .044 .040 .051 12.60 L.4.hydroxy.L.proline 8.812 6.417 12.451 .685 .554 .938 12.73 Ornithine 65.407 51.951 79.256 5.250 4.162 6.138 12.83 Citrulline 28.087 23.808 35.088 2.151 1.697 2.619 13.21 Glutathione 5.661 4.636 6.485 .400 .312 .493 14.56 L.Tryptophan 57.474 51.837 61.938 2.284 2.000 2.700 24.75 Glycine 289.064 235.273 334.399 8.261 7.287 9.859 32.34 L.Pipecolic.acid 10.778 8.670 14.545 .323 .257 .403 35.21 L.Glutamic.acid 40.028 32.485 54.316 .387 .355 .478 107.70 L.Proline 171.004 140.167 209.404 .984 .805 1.235 181.27 Metabolites are ranked by plasma/CSF ratio from smallest to largest ratio. The table is based on uncorrected data. †CSF = cerebrospinal fluid. Q1 = First quartile; Q3 = Third quartile.
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