CORRELATING RATIOS OF AMINES IN PLASMA AND CEREBROSPINAL FLUID 69 3 Table 6 Plasma and CSF concentrations in migraine with aura participants. Metabolite Plasma (µM) CSF† (µM) Plasma /CSF Ratio Median Q1 Q3 Median Q1 Q3 Median Ethanolamine 11.578 10.470 12.732 20.911 18.792 22.715 .55 Putrescine .096 .079 .119 .157 .122 .198 .63 L.Glutamine 653.450 586.971 711.809 567.820 516.139 615.613 1.15 N6.N6.N6.Trimethyl.L.lysine .469 .395 .564 .396 .364 .433 1.18 O.Phosphoethanolamine 9.092 6.046 13.232 6.789 6.028 7.943 1.24 Gamma.aminobutyric.acid .141 .126 .162 .098 .073 .123 1.46 L.Homoserine .132 .117 .147 .060 .053 .065 2.28 Gamma.Glutamylglutamine 5.079 4.119 5.593 1.968 1.682 2.271 2.52 L.Arginine 72.078 60.850 81.213 22.499 19.179 24.445 3.22 SDMA .575 .511 .640 .155 .135 .182 3.58 L.Threonine 131.388 114.403 146.662 37.090 30.923 41.640 3.61 L.Serine 109.030 93.263 124.880 28.032 24.813 32.959 3.86 L.Histidine 60.959 55.442 65.949 14.569 13.181 16.302 4.12 Homocitrulline .221 .183 .321 .049 .039 .066 4.78 L.Phenylalanine 55.540 50.081 60.634 10.001 8.832 11.155 5.47 L.Alpha.aminobutyric.acid 18.415 15.313 21.751 3.141 2.386 4.094 5.78 L.Tyrosine 49.443 42.673 56.030 8.247 6.846 9.526 5.81 L.Methionine 22.550 20.440 24.734 3.704 3.175 4.290 5.87 3.Methoxytyrosine .088 .077 .105 .014 .013 .017 6.05 Methionine.sulfone .290 .230 .363 .048 .036 .061 6.21 L.Asparagine 49.761 46.959 54.779 7.571 6.818 8.638 6.57 L.Lysine 188.289 171.233 214.701 29.191 25.893 32.633 6.64 L.Methionine.sulfoxide .730 .624 .828 .098 .079 .120 7.51 S.Methylcysteine 3.529 2.837 4.965 .491 .364 .640 7.56 L.2.aminoadipic.acid .716 .593 .899 .088 .074 .102 8.26 L.Leucine 264.337 240.759 307.927 32.152 27.056 37.816 8.44 L.Isoleucine 112.672 99.368 130.394 10.764 9.395 12.632 10.49 L.Alanine 379.229 326.339 442.442 34.173 30.171 40.508 10.74 Taurine 83.719 64.708 113.254 7.117 6.093 8.013 11.14 L.Valine 235.246 213.624 269.877 21.665 16.751 24.563 11.86 L.4.hydroxy.L.proline 7.770 6.020 10.363 .644 .485 .832 12.10 Gamma.L.glutamyl.L.alanine .540 .462 .651 .042 .037 .048 12.55 Citrulline 27.375 22.837 31.007 2.021 1.758 2.428 12.69 Ornithine 62.759 51.411 78.293 5.143 4.161 6.015 13.09 Glutathione 5.404 4.490 6.696 .327 .267 .445 15.62 L.Tryptophan 54.546 47.679 59.223 2.338 2.098 2.608 23.17 Glycine 286.608 235.756 352.980 8.037 7.021 10.223 34.24 L.Pipecolic.acid 10.626 8.529 12.854 .313 .258 .397 34.61 L.Glutamic.acid 39.946 28.893 58.014 .391 .359 .458 99.13 L.Proline 168.383 133.030 213.782 .910 .749 1.177 174.50 Metabolites are ranked by plasma/CSF ratio from smallest to largest ratio. The table is based on uncorrected data. †CSF = cerebrospinal fluid. Q1 = First quartile; Q3 = Third quartile.
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