3 CHAPTER 3 70 Table 7 Plasma/CSF correlations for single metabolites in migraine participants MO MA Metabolite r R2 95% c.i. FDR r R2 95% c.i. FDR S-Methylcysteine .84 .71 .60 - .80 4.44E-26 .86 .74 .64 - .82 1.04E-28 Methionine sulfone .79 .63 .50 - .74 2.94E-21 .79 .62 .49 - .73 3.25E-21 Homocitrulline .78 .61 .47 - .72 2.86E-20 .72 .51 .36 - .64 8.16E-16 L-Alpha-aminobutyric acid .73 .54 .39 - .66 9.66E-17 .80 .63 .50 - .74 1.43E-21 L-Threonine .68 .47 .31 - .61 6.85E-14 .62 .39 .23 - .53 4.40E-11 L-4-hydroxy-L-proline .63 .40 .24 - .55 1.86E-11 .64 .41 .26 - .56 6.02E-12 L-Arginine .56 .32 .17 - .47 9.56E-09 .45 .21 .08 - .36 7.27E-06 3-Methoxytyrosine .55 .30 .15 - .45 2.93E-08 .60 .36 .20 - .51 3.77E-10 Citrulline .54 .29 .15 - .45 3.71E-08 .48 .23 .09 - .38 2.25E-06 L-Alanine .54 .29 .14 - .45 3.71E-08 .44 .19 .07 - .34 1.84E-05 L-Lysine .53 .28 .14 - .44 5.99E-08 .35 .13 .03 - .27 5.73E-04 L-Pipecolic acid .52 .27 .12 - .42 1.57E-07 .56 .32 .17 - .47 6.38E-09 L-Tyrosine .48 .23 .10 - .39 1.55E-06 .51 .26 .12 - .41 3.72E-07 Ornithine .46 .21 .08 - .37 4.85E-06 .33 .11 .02 - .24 1.66E-03 L-Asparagine .45 .21 .08 - .36 7.05E-06 .37 .14 .03 - .28 2.96E-04 Glycine .41 .17 .05 - .32 7.11E-05 .36 .13 .03 - .27 4.58E-04 L-Proline .38 .15 .04 - .29 2.27E-04 .47 .22 .09 - .38 2.78E-06 L-Valine .37 .14 .03 - .28 3.74E-04 .38 .14 .04 - .29 2.23E-04 N6-N6-N6-Trimethyl-L-lysine .36 .13 .03 - .28 5.13E-04 .43 .18 .06 - .34 2.53E-05 L-Glutamine .35 .12 .02 - .26 9.34E-04 .40 .16 .05 - .31 8.91E-05 L-Histidine .32 .11 .02 - .24 2.03E-03 .25 .06 .00 - .19 1.54E-02 L-Isoleucine .32 .10 .02 - .24 2.04E-03 .22 .05 .00 - .16 4.06E-02 Gamma-L-glutamyl-L-alanine .31 .09 .01 - .23 3.78E-03 .21 .04 .00 - .15 4.76E-02 L-2-aminoadipic acid .30 .09 .01 - .22 4.49E-03 .41 .16 .05 - .31 8.31E-05 Putrescine .29 .08 .01 - .21 6.09E-03 .19 .04 .00 - .14 7.30E-02 L-Serine .28 .08 .01 - .21 7.59E-03 .40 .16 .05 - .31 8.41E-05 L-Leucine .25 .06 .00 - .18 1.94E-02 .29 .08 .01 - .21 5.45E-03 SDMA .23 .05 .00 - .17 2.88E-02 .10 .01 .00 - .09 3.79E-01 L-Methionine .21 .04 .00 - .15 5.37E-02 .30 .09 .01 - .22 4.12E-03 L-Methionine sulfoxide .20 .04 .00 - .15 6.20E-02 .19 .04 .00 - .14 6.49E-02 Gamma-Glutamylglutamine .13 .02 .00 - .11 2.42E-01 .23 .05 .00 - .17 2.79E-02 Ethanolamine .12 .01 .00 - .10 3.11E-01 .40 .16 .05 - .31 8.79E-05 Gamma-aminobutyric acid -.11 .01 .00 - .09 3.29E-01 .04 .00 .00 - .06 7.21E-01 Taurine -.11 .01 .00 - .09 3.35E-01 .20 .04 .00 - .15 6.29E-02 L-Homoserine .11 .01 .00 - .09 3.37E-01 .32 .10 .02 - .24 2.19E-03 L-Phenylalanine -.05 .00 .00 - .06 6.95E-01 .33 .11 .02 - .25 1.59E-03 L-Glutamic acid .04 .00 .00 - .06 7.15E-01 .05 .00 .00 - .06 6.31E-01 Glutathione .03 .00 .00 - .05 7.67E-01 .09 .01 .00 - .08 3.91E-01 L-Tryptophan -.03 .00 .00 - .05 7.67E-01 .08 .01 .00 - .08 4.36E-01 Metabolites are ranked by value of this coefficient and values ≥ .7 are printed in bold.Table is based on corrected data. r = Pearson correlation coefficient; R2 = coefficient of determination; 95% c.i. = 95% confidence interval of R2; FDR = false discovery rate MO = migraine with aura, MA = migraine without aura.
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