CORRELATING RATIOS OF AMINES IN PLASMA AND CEREBROSPINAL FLUID 71 3 Conflict of interest statement: The authors declare no conflict of interest. Author's contributions: Conceptualization: A.V.E.H., J.B.v.K., R.M.v.D., G.L.J.O., T.H., G.M.T. and A.M.J.M.v.d.M.; Methodology: A.V.E.H., J.B.v.K., R.M.v.D., and A.C.H.; Investigation: R.M.v.D., G.L.J.O., and A.C.H.; Formal analysis: A.V.E.H., J.B.v.K. and R.M.v.D.; Resources: T.H., M.D.F., G.M.T. and A.M.J.M.v.d.M.; Data curation: A.V.E.H., J.B.v.K., R.M.v.D., G.L.J.O. A.C.H.; Writing – original draft: A.V.E.H., J.B.v.K. and R.M.v.D.; Writing – review & editing: G.L.J.O., A.C.H., T.H., G.M.T. and A.M.J.M.v.d.M.; Visualisation: A.V.E.H., J.B.v.K. and R.M.v.D.; Supervision: T.H., G.M.T. and A.M.J.M.v.d.M.; Project administration: A.V.E.H., R.M.v.D., and G.L.J.O.; Funding acquisition: T.H., G.M.T. and A.M.J.M.v.d.M. Funding information: This work was supported by the Netherlands Organization for Scientific Research (VICI grant 918.56.601 and Spinoza 2009 to M.D.F.), the Netherlands Organization for Health Research and Development (Clinical Fellowship grant 90700217 and Vidi grant 91711-31 to G.M.T.), and European Community-funded FP7-EUROHEADPAIN (grant 602633 to M.D.F. and A.M.J.M.v.d.M.). Data accessibility statement: Data not published within the article is available from the corresponding author upon reasonable request. Supplementary information Figure S1 Remaining correlation plots of amines between plasma and CSF in healthy controls. Figure S2 Correlation matrix of all possible metabolite ratios in healthy controls split by sex. Figure S3 The difference in coefficients of determination (R2) of all possible metabolite ratios in migraine participants compared to healthy controls. Table S1 Single-plasma/CSF metabolite correlations in heathy controls. Table S2 Plasma/CSF ratio metabolite correlations in heathy controls. Table S3 The improvement in R2 ratio correlation (R2 gain) compared to r in healthy controls. Table S4 Single-plasma/CSF metabolite correlations in migraine participants. Table S5 Plasma/CSF ratio metabolite correlations in migraine participants. Table S6 Comparison of single-metabolite correlations of plasma and CSF between heathy controls and migraine participants. Table S7 Comparison of plasma/CSF ratio metabolite correlations between heathy controls and migraine participants.
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