Aster Harder

Chapter 1 General introduction	7
Chapter 2 Metabolic profile changes in serum of migraine patients detected using H-NMR spectroscopy 1	29
Chapter 3 Correlation between plasma and CSF concentrations of amines	49
Chapter 4 Endocannabinoid cerebrospinal fluid levels in migraine	75
Chapter 5 Prostaglandin-E2 levels over the course of glyceryl trinitrate provoked migraine attacks	95
Chapter 6 Genetic susceptibility loci in genome-wide association study of cluster headache	115
Chapter 7 Cluster headache genome-wide association study identifies eight loci and implicates smoking as causal risk factor	137
Chapter 8 Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles	159
Chapter 9 Whole exome sequencing of hemiplegic migraine patients shows an increased burden of missense variants in CACNA1H and CACNA1I genes	191
Chapter 10 General discussion	209
Summary	236
Nederlandse samenvatting	241
List of publications	247
About the author	249
Dankwoord	250

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