121 Systemic Immune Response in Burn Patients counts (Figure 1C). The relative amounts of leukocyte subtypes are summarized in Figure 1E. We observed no confounding effect of TBSA (>26% vs. ≤26%) on the course of the inflammatory response (i.e. leukocytes, granulocytes, lymphocytes, and monocytes) in the mixed model analysis (data not shown). Figure 1. Blood immune cells after severe burn injury. Flow cytometry was used for phenotyping of leukocytes: (A) Total leukocyte numbers (gray). (B) Granulocyte numbers (red). (C) Lymphocyte numbers (blue). (D) Monocyte numbers (green). (E) Relative amount of leukocyte subtypes. Number of subjects per time interval is shown on top of the graphs. Values of burn wound patients and healthy controls (HC) are shown as mean (line and dots) ± standard deviation (colored band). Asterisks indicate significant differences in time within the burn patient group (linear mixed model analysis): *p < 0.05; **p < 0.01. Significant differences of outcomes in burn patients of PBD 0-3 compared to healthy controls are indicated by × (×××p < 0.001). 4
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