14 Chapter 1 Table 1. Continued. Category Mediator Source Function Growth factors EGF Glands, platelets Stimulates growth of epidermal and epithelial cells FGF (1-23) Macrophages Proliferation of fibroblasts, induce production of granulation tissue G-CSF Endothelial cells, macrophages Stimulates bone marrow to release granulocytes into blood GM-CSF T cells, macrophages, endothelial cells, fibroblasts Maturation of granulocytes and monocytes KGF (FGF7) Mesenchymal cells, fibroblasts Induces re-epithelization by keratinocytes PDGF Platelets Stimulates growth of mesenchymal cells, promotes wound healing PGE Macrophages Pro-inflammatory, vasodilator, inhibits aggregation of platelets TGF-β1 Platelets, fibroblasts, monocytes, T cells Anti-inflammatory, regulates cell growth, inhibition of lymphocytes VEGF (A-F) Macrophages, platelets, keratinocytes Stimulates angiogenesis Other mediators CRP Liver Pro-inflammatory, acute phase protein, stress response Histamine Mast cells, basophils Anti-pathogen response, allergic reaction HMGB1 Damaged cells Pro-inflammatory, DAMP, stress response
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