187 Full Skin Equivalent Model for Burn Wound Healing human skin model and the DED-based FSE. In the MatriDerm-based FSE, BrdU-positive keratinocytes were only present at the leading edge of the neo-epidermis. Similar to Ki67, only very few BrdU-positive cells were present in Mucomaix-based models. The length of re-epithelization at T + 1 week of the DED- and Matriderm-based models was larger than in the ex vivo human skin model (Figure 5C). The length of the re-epithelized area of the wound in DED- and MatriDerm-based models at T + 2 weeks, however, was comparable to that of the ex vivo human skin model. Mucomaix-based models, on the other hand, lacked the capacity to regenerate the burned epidermis. Thus, the DED- and MatriDerm-based models showed regenerative capacity with a neo-epidermis that contained proliferating cells, while regeneration in Mucomaix-based FSEs was not observed. 6
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