197 Full Skin Equivalent Model for Burn Wound Healing medium changes. When cytokine levels were out of range of the standard, either the lowest level of quantification or the highest level of quantification was used. Statistical analysis and data visualization Differences in re-epithelization length and cytokine levels between different time points were explored using the Mann-Whitney U tests in Graphpad version 5.01 (PRISM, La Jolla, CA, USA), and only significant differences were shown in the graphs. A p-value of <0.05 was considered to be statistically significant. The data were visualized using Graphpad version 5.01 and R (ggplot package, open source). ACKNOWLEDGMENTS We want to thank Judith Huijgen, Leonore Mastenbroek, and Serena van den Berg of the Association of Dutch Burn Centres for their technical assistance. MatriDerm® was kindly provided as research material by MedSkin Solutions, Dr. Suwelack AG, Billerbeck, Germany. Mucomaix® was kindly provided by Matricel GmbH, Hertzogenrath, Germany. DED was kindly provided by the European Tissue Bank BISLIFE, Beverwijk. This research was funded by the Dutch Burns Foundation under grant numbers WO/16.02 (BKHLB) and WO/17.108 (BKHLB) and by Health-Holland under grant number LSHM16052-HSGF (BKHLB). 6
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