216 Chapter 7 the FSEs were CD25+, confirming that the migrated T cells were indeed activated (Figure 4D). The percentage of CD25+CD127¯ T cells, which might be an indication for Tregs, was higher in the FSEs than for the T cells cultured in suspension (Figure 4E). In FSEs, a clear increase in the percentage of CXCR3+ T cells was observed, which is indicative of Th1 activity (Figure 4F). Similarly, we observed an increase in the percentage of CCR4+CCR6+ T cells in the FSEs, suggesting enhanced Th17 activity (Figure 4G). On average the number of T cells in burn-injured FSEs was similar to that found in uninjured FSEs. Burn injury did not affect the analyzed T cell markers. Together, it was shown that particularly activated T cells migrated into FSEs and that Treg and Th1/Th17 activation might be enhanced, irrespective of burn injury.
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