34 Chapter 2 total body surface area (TBSA) than in those using 5‒25% TBSA and were highest in rats. Sensitivity analysis showed that the effect of TBSA was present in mice but not in rats. Surprisingly, neutrophil wound counts in studies using 5‒25% TBSA were lower than in those using ≤5% TBSA, in both mice and rats. Blood neutrophil counts were higher in males than in females. Interestingly, both wound leukocyte and neutrophil counts were lower in scalds than in metal burns. Within TBSA groups, the difference in neutrophil counts between species was still present in wound tissue but not in blood, indicating that collinearity could play a role. The difference between sexes for blood counts and the effect of metal burns on wound neutrophil counts were not influenced by TBSA or species. Because the majority of the studies used full-thickness burns, subgroup analysis on wound depth could only be performed for wound neutrophil counts. Overall, the leukocyte response was affected by type of species, animal age, and burn agent, whereas the neutrophil counts depended on species, sex, wound size, and burn agent.
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