TABLE OF CONTENT Chapter 1 General Introduction 7 Part 1 Immune Response in Animal Burn Models 23 Chapter 2 Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies 25 Chapter 3 Kinetics of Inflammatory Mediators in the Immune Response to Burns: Systematic Review and Meta-Analysis of Animal Studies 61 Part 2 Immune Response in Burn Patients 115 Chapter 4 Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles 117 Chapter 5 Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and proinflammatory cytokines 149 Part 3 In Vitro Modeling 177 Chapter 6 Full Skin Equivalent Models for Simulation of Burn Wound Healing, Exploring Skin Regeneration and Cytokine Response 179 Chapter 7 Monocytes and T cells Incorporated in Full Skin Equivalents to Study Innate or Adaptive Immune Reactions after Burn Injury 209 Discussion and Summary 235 Chapter 8 General Discussion 237 Chapter 9 English Summary 257 Chapter 10 Dutch Summary - Nederlandse Samenvatting 265 Appendix 271 Scientific Output 272 Portfolio 276 Data Management Plan 278 Acknowledgements - Dankwoord 280 About the Author 286
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