57 Review Immune Cells in Animal Burn Models Supplementary Table 1. Outcome measures and references used in systematic review and meta-analysis. A minimum of 5 articles was required for inclusion of a defined outcome measure in the meta-analysis. For cell function apoptosis, no cell type reached this minimum. Cell type Outcome data in meta-analysis (number of studies) References in systematic review Neutrophils (granulocytes, polymorphonuclear cells) • Blood immune cell count (50) • Wound immune cell count (48) • Migration (10) • Antibacterial function (9) • ROS production (16) • Inflammatory mediator production (8) 29, 48, 76, 218–222, 227, 229–231, 235, 77, 259, 281, 305, 78–81, 83, 85–87, 57, 88, 89, 91, 93, 95, 96, 98–101, 60, 102, 107, 108, 110, 112, 114–118, 61, 121, 123, 126, 128, 129, 131–135, 62, 136, 138–140, 142, 144, 145, 147, 148, 150, 63, 151, 155–158, 161–163, 165, 166, 67, 170–177, 181, 182, 70, 183, 184, 186, 191–193, 196, 198–200, 73, 203, 204, 206, 207, 210–213, 215, 217 Leukocytes (white blood cells, inflammatory cells) • Blood immune cell count (45) • Wound immune cell count (14) • Migration (11) 59, 60, 75, 76, 78, 89, 91, 92, 95, 100, 101, 104, 61, 106, 107, 111, 113, 118, 140, 141, 143, 151, 154, 62, 156–158, 160, 162–164, 168, 169, 178, 63, 179–181, 186–190, 192, 194, 65, 205, 208, 214, 216, 219, 223, 224, 227, 228, 232, 69, 233, 258, 305, 306, 71, 72, 74 Lymphocytes • Blood immune cell count (25) 48, 60, 106, 118, 128, 142–144, 151–153, 157, 61, 158, 163, 170, 181, 184, 186, 195, 209, 219, 262, 62, 266, 286, 288, 290, 67, 69, 75, 76, 91, 95] Monocytes • Blood immune cell count (24) 48, 58, 111, 118, 128, 140, 142, 144, 151, 156, 157, 163, 60, 181, 186, 217, 230, 236, 243, 61, 64, 67, 69, 76, 89, 95 Macrophages (monocytes in wound tissue) • Wound immune cell count (21) • Inflammatory mediator production (9) 61, 73, 109, 120, 124, 125, 127, 130, 159, 165, 202, 208, 75, 210, 219–221, 225, 229, 231, 233, 234, 262, 79, 274, 281, 282, 296, 307, 84, 94, 97, 98, 103, 108 Thrombocytes (platelets) • Blood immune cell count (14) 59, 67, 219, 223, 227, 230, 273, 74, 92, 101, 121, 157, 158, 181, 201 Mast cells • Wound immune cell count (9) 66, 105, 109, 119, 167, 208, 215, 225, 226 2
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