64 Chapter 3 research basis that is useful to refine experimental set-ups and design (targeted) interventions to improve treatment of burn patients. RESULTS Study selection and study characteristics The study protocol was published on PROSPERO and was amended once to further specify the meta-analyses. Our search generated 11,375 records, of which 1,387 were considered relevant during title and abstract screening (Figure 1). From this selection, the full-text versions of 115 studies were inaccessible and a total of 424 studies were included in the systematic review from which 352 were used for meta-analyses (Supplementary Table 1 and Supplementary Table 2). Supplementary Figure 1 displays an overview of the characteristics of the included studies. The vast majority of studies used rats or mice, mostly young and male. Most studies produced a full-thickness injury using hot water or contact with hot objects on the dorsal area. Size of burn injuries varied from 80 studies with ≤5%, 132 with 5-25% and 189 with >25% of total body surface area (TBSA).
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