Patrick Mulder

70 Chapter 3 Figure 5. Longitudinal analysis of inflammatory mediator levels after burn injury. Subgroup analysis of different time intervals after burn injury on the inflammatory mediators levels in (A) blood or (B) burn wound tissue. Only time intervals containing at least 10 studies are shown. Results are shown as SMD of levels of inflammatory mediators in burn-injured animals compared to uninjured animals ± CI95%. There is a statistically significant difference with uninjured animals when the CI95% does not cross the x-axis. The I 2 statistic, number of studies and total number of animals used in the burn-injured group for each meta-analysis are shown below the graphs. Bonferronicorrected p-values based on the CI95% of the difference between time intervals are indicated by black asterisks: *p < 0.05; **p < 0.01; ***p < 0.001. CI95%, 95% confidence interval; SMD, standardized mean difference.

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