72 Chapter 3 Figure 6. Subgroup analysis of inflammatory mediator levels based on type and severity of burn injury. Subgroup analysis of percentage of total body surface area, wound depth, injury site and type of burn agent on the inflammatory mediator levels in (A) blood or (B) burn wound tissue. Only subgroups containing at least 10 studies are shown. Results are shown as SMD of levels of inflammatory mediators from burn-injured animals compared to uninjured animals ± CI95%. There is a statistically significant difference with uninjured animals when the CI95% does not cross the x-axis. The I2 statistic, number of studies and total number of animals used in the burn-injured group for each meta-analysis are shown below the graphs. Bonferroni-corrected p-values based on the CI95% of the difference between subgroups are indicated by black asterisks: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. CI95%, 95% confidence interval; SMD, standardized mean difference. The level of inflammatory mediators is dependent on species, sex, age and detected form There was great variation among the experimental models used to study the burninduced immune response. As animal characteristics can impact outcome data, we explored differences in the levels of inflammatory mediators between diverse
RkJQdWJsaXNoZXIy MTk4NDMw