74 Chapter 3 Figure 7. Subgroup analysis of inflammatory mediator levels after burn injury based on model characteristics. Subgroup analysis of animal species, sex, age and detected form on the inflammatory mediator levels in (A) blood or (B) burn wound tissue. Only subgroups containing at least 10 studies are shown. Results are shown as SMD of levels of inflammatory mediators from burn-injured animals compared to uninjured animals ± CI95%. There is a statistically significant difference with uninjured animals when the CI95% does not cross the x-axis. The I 2 statistic, number of studies and total number of animals used in the burn-injured group for each meta-analysis are shown below the graphs. Bonferroni-corrected p-values based on the CI95% of the difference between subgroups. Significant differences are indicated by black asterisks: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. CI95%, 95% confidence interval; SMD, standardized mean difference.
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