82 Chapter 3 the animals, and Meeh-Rubner’s formula () [84]. The following K values were used: 9.0 (mouse), 9.8 (rat), 10.0 (pig), 10.1 (dog), 10.4 (cat) 10.5 (guinea pig), and 12.0 (rabbit). When total body surface area was missing in included articles, it was estimated on the basis of the reported age and weight information available at Animal Resources Centre (https://www.arc.wa.gov.au/), The Jackson Laboratory (https://www.jax.org/), and Roysfarm (https://www.roysfarm.com/). Using the weight of the animal, the animal’s age was estimated when this was not reported. Animal age subgroups, young or adult, were based on the social maturity of the animals: adults were aged >12 weeks (hamster), >3 months (mouse), >6 months (rat, cat, pig or Guinea pig), and >12 months (rabbit or dog). For wound depth, the following categories were used: superficial (first degree), partial-thickness (second degree), deep dermal (deep second degree), and full-thickness (third degree, fourth degree, severe burn injury). Meta-regression Meta-regression analyses were performed post-hoc on the standardized mean difference of inflammatory mediator levels using the reported percentage of TBSA as a continuous variable. Random effects‒restricted maximum likelihood model was used, and repeated measures (same animal, multiple sampling times) of studies were included. Studies included in meta-analysis [50,85–435] Studies included in systematic review [50,85–507] Studies with uninjured controls that were used for risk of bias assessment [114,116,130,131,154,171,198,221,224,234,244,259,263,288,290,301,304,310,325,345,3 97,434,444,454,508] Baseline-controlled studies that were used for risk of bias assessment [92,102,106,121,125,207,241,283,307,311,314,369,386,411,415– 419,440,441,450,467,468,476,477,482,484,486,509] ACKNOWLEDGMENTS We want to thank Alice Tillema of the Radboud Medical Library for her help in designing the search strategy, dr. Rob de Vries of SYRCLE for his advice and dr. Kim Schilders, Anouk Elgersma, Rosa Rentenaar and Myrthe Witbaard of the ADBC for their assistance during data extraction. This research was funded by the ZonMw program More Knowledge with
RkJQdWJsaXNoZXIy MTk4NDMw