Patrick Mulder

Chapter 1 General Introduction	7
Part 1 Immune Response in Animal Burn Models	23
Chapter 2 Burn-Induced Local and Systemic Immune Response: Systematic 25 Review and Meta-Analysis of Animal Studies	25
Chapter 3 Kinetics of Inflammatory Mediators in the Immune Response to 61 Burns: Systematic Review and Meta-Analysis of Animal Studi	61
Part 2 Immune Response in Burn Patients	115
Chapter 4 Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles	117
Chapter 5 Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro inflammatory cytokines	149
Part 3 In Vitro Modeling	177
Chapter 6 Full Skin Equivalent Models for Simulation of Burn Wound Healing, Exploring Skin Regeneration and Cytokine Response	179
Chapter 7 Monocytes and T cells Incorporated in Full Skin Equivalents to Study Innate or Adaptive Immune Reactions after Burn Injury	209
Discussion and Summary	235
Chapter 8 General Discussion	237
Chapter 9 English Summary	257
Chapter 10 Dutch Summary - Nederlandse Samenvatting	265
Appendix	271
Scientific Output	272
Portfolio	276
Data Management Plan	278
Acknowledgements - Dankwoord	280
About the Author	286

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