Henk-Jan Boersema

72 Chapter 4 Table 3 Population attributable fractions and associations of each disease group with the inability to work fulltime (univariable and multivariable logistic regression analyses, adjusted for gender, age, educational level and multimorbidity) (n = 30,138) PAF Univariable analyses Multivariable analyses % OR 95% CI p-value OR 95% CI p-value Infectious and parasitic diseases 0.26 2.44 1.74–3.43 < .001 2.40 1.70–3.37 < .001 Neoplasms 5.17 3.53 3.19–3.91 < .001 3.18 2.87–3.53 < .001 Diseases of the blood and bloodforming organs 0.92 4.58 3.54–5.93 < .001 4.35 3.36–5.65 < .001 Endocrine, nutritional and metabolic disorders 0.21 1.24 1.03–1.48 .021 1.20 1.00–1.44 .051 Mental and behavioural disorders 2.03 1.12 1.07–1.18 < .001 1.13 1.07–1.19 < .001 Diseases of the nervous system 2.98 2.51 2.26–2.78 < .001 2.42 2.18–2.69 < .001 Diseases of the eye and adnexa - 0.10 0.84 0.65–1.07 .150 0.77 0.60–0.98 .037 Diseases of the ear and mastoid process 0.03 1.07 0.83–1.37 .599 0.95 0.74–1.22 .705 Diseases of the circulatory system 4.64 2.61 2.39–2.85 < .001 2.75 2.52–3.01 < .001 Diseases of the respiratory system 1.87 3.20 2.75–3.71 < .001 3.34 2.87–3.89 < .001 Diseases of the digestive system 0.84 2.40 1.99–2.89 < .001 2.83 1.97–2.88 < .001 Diseases of the skin and subcutaneous tissue - 0.17 0.50 0.34–0.74 .001 0.52 0.35–0.77 .001 Diseases of the musculoskeletal system and connective tissue - 19.29 0.29 0.27–0.31 < .001 0.29 0.27–0.30 < .001 Diseases of the genitourinary system 0.61 2.94 2.29–3.78 < .001 2.87 2.23–3.69 < .001 Pregnancy, childbirth and the puerperium - 0.16 0.50 0.33–0.74 .001 0.46 0.31–0.69 < .001 Congenital malformations, deformations and chromosomal abnormalities 0.14 1.61 1.15–2.25 .005 1.64 1.17–2.30 .004 Symptoms, signs and abnormal clinical and laboratory findings - 1.91 0.60 0.53–0.67 < .001 0.60 0.53–0.67 < .001 Injury, poisoning and certain other consequences of external causes - 2.30 0.54 0.49–0.60 < .001 0.56 0.50–0.62 < .001 PAF population attributable fraction, OR odds ratio, CI confidence interval

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