127 Genome-wide analysis in E. coli unravels homoplasy associated with cefotaxime resistance a blaCTX-M-27 gene combined with a blaCMY-2 gene (ampC_0114), but was ESBL disc test negative (see Table S1). In 21 (12.2%) of the isolates, neither pampC nor described mutations related to AmpC hyperproduction were detected and are noted as putative low-level AmpC producers. Table 1. Table of the distribution of the different AmpC promoter and attenuator variants, as well as the numbers of different MLST STs and phylogroups per grouped genotype (pampC, putative hyperproducers and putative low-level AmpC producers) Genotype Isolate Promoter variant Attenuator variant MLST Phylogroup pampC n=90 3 variants 6 variants 44 STs and 4 unknown Putative hyperproducers n=61 13 variants 14 variants 30 STs and 5 unknown Putative low-level AmpC producers n=21 8 variants 5 variants 14 STs and 4 unknown Total n=172 21 variants 18 variants 75 STs and 13 unknown 7
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