131 Genome-wide analysis in E. coli unravels homoplasy associated with cefotaxime resistance Figure 4. circos plot for the full chromosome of ampC_0069 (accession no. CP046396) with, per position, the various metrics used. (a) The blue coloured ring represents the consistency index results per genomic position. The two red dots indicate the −42 and −32 position on the promoter. The black circle line indicates the 0.07142857 consistency index value. (b) The ring with a red background shows all positions that were significantly associated with CTX resistance in all non-pampC-harbouring E. coli isolates. Larger bars pointing outwards indicate multiple significant associated positions in a small genomic region. (c) The ring with the green background shows all 24 positions that have a low consistency index of ≤0.05882353 and are significantly associated with CTX resistance in all non-pampC-harbouring E. coli isolates. 7
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