45 Decline in AmpC beta-lactamase-producing E. coli in a Dutch teaching hospital Conclusions Four yearly point prevalence surveys show that rectal carriage of both pAmpC and cAmpC beta-lactamase producing E. coli and Klebsiella spp. was low. This study shows a significant decline in rectal carriage of E. coli with cAmpC promotor/attenuator alterations in hospitalised patients in a Dutch teaching hospital during this four-year period. The underlying reasons are unclear and deserve further investigations as they may provide new insights to further control antimicrobial resistance. 3
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