Table of contents Chapter 1 General introduction 11 Chapter 2 AmpC beta-lactamases: epidemiology, infection control and treatment 19 Chapter 3 Decline in AmpC beta-lactamase-producing Escherichia coli in a Dutch teaching hospital (2013-2016) 33 Chapter 4 Development of an algorithm to discriminate between plasmid- and chromosomal-mediated AmpC beta-lactamase production in Escherichia coli by elaborate phenotypic and genotypic characterization 49 Chapter 5 Detection of AmpC beta-lactamases in Escherichia coli using different screening agars 79 Chapter 6 Limited genetic diversity of blaCMY-2-containing IncI1-pST12 plasmids from Enterobacteriaceae of human and broiler chicken origin in the Netherlands 95 Chapter 7 Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance 117 Chapter 8 In silico estimates of plasmid copy number are associated with increased resistance to cefotaxime, ceftazidime, and piperacillin/ tazobactam in CMY-2-producing Escherichia coli 145 Chapter 9 Summary and general discussion 161 Closing pages 169 References 189
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