Evert den Drijver

Chapter 1 General introduction	11
Chapter 2 AmpC beta-lactamases: epidemiology, infection control and treatment	19
Chapter 3 Decline in AmpC beta-lactamase-producing Escherichia coli in a Dutch teaching hospital (2013-2016)	33
Chapter 4 Development of an algorithm to discriminate between plasmidand chromosomal-mediated AmpC beta-lactamase production in Escherichia coli by elaborate phenotypic and genotypic characterization	49
Chapter 5 Detection of AmpC beta-lactamases in Escherichia coli using different screening agars	79
Chapter 6 Limited genetic diversity of blaCMY-2-containing IncI1-pST12 plasmids from Enterobacteriaceae of human and broiler chicken origin in the Netherlands	95
Chapter 7 Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance	117
Chapter 8 In silico estimates of plasmid copy number are associated with increased resistance to cefotaxime, ceftazidime, and piperacillin/tazobactam in CMY-2-producing Escherichia coli	145
Chapter 9 Summary and general discussion	161
Closing pages	169
References	189

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